Early reactivation of medial temporal lobe neurons during emergence from propofol anesthesia in neurosurgical patients.
bioRxiv : the preprint server for biology May 26, 2026 Joel I Berger, Matthew I Banks, Emily R Dappen et al. preprint
Although much is known about the molecular and cellular effects of general anesthetics, the neural mechanisms underlying loss and recovery of consciousness during anesthesia remain elusive. We provide the first report of human single neuron activity recorded throughout emergence from general anesthesia. Following cessation of propofol infusion, emergence was assessed as motor response to verbal...