Alleviating role of ketamine in breast cancer cell-induced osteoclastogenesis and tumor bone metastasis-induced bone cancer pain through an SRC/EGR1/CST6 axis.
BMC cancer December 18, 2024 Xiaomin Zhang, Yanmei Zhang, Wei Du 5 citations
The analgesic effect of ketamine in cancer pain remains controversial. This research investigates the role of ketamine in bone metastasis-induced cancer pain in breast cancer (BC) and its associated molecular network. BC cell lines MDA-MB-231 and ZR-75-1 were treated with ketamine and malignant behaviors were assessed through CCK-8, colony formation, and Transwell assays. To evaluate the...
DOI: 10.1186/s12885-024-13290-7 (opens in new tab)
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Bone cancer pain
Cst6
Egr1
Src
+9