Siyu Chen

Dissociation-related behaviors in mice emerge from the inhibition of retrosplenial cortex parvalbumin interneurons.

Cell Reports January 28, 2025 Yue Hu, Yifan Feng, Huoqing Luo et al. 6 citations

Dissociation, characterized by altered consciousness and perception, underlies multiple mental disorders, but the specific neuronal subtypes involved remain elusive. In mice, we find that dissociation-inducing doses of ketamine significantly inhibit retrosplenial cortex (RSC) parvalbumin interneurons (PV-INs), enhancing delta oscillations (1-3 Hz) and delta-gamma phase-amplitude coupling (δ-γ...