Ketamine as a potential cognitive enhancer in neurological disorders: evidence from preclinical and clinical studies
Frontiers in Neurology March 30, 2026 Jose E. Leon-Rojas, Guido Mascialino, Lizeth Vinueza Mera et al. 2 citations
Subanesthetic ketamine shows rapid neuroplastic and antidepressant effects in psychiatric conditions, prompting interest in its potential relevance for cognitive dysfunction in neurological disorders. Cognitive deficits are widespread across traumatic brain injury, stroke, epilepsy, and neurodegenerative diseases, yet treatments remain primarily compensatory. Ketamine's actions on glutamatergic...