Efficacy of perioperative esketamine on postoperative depression: a systematic review and meta-analysis
Frontiers in Psychiatry April 15, 2025 Hao-Yan Li, Wen-jing Xu, Ya-Mei Wang et al.
Background Postoperative depression (POD) represents a serious complication in surgical patients, exacerbating morbidity and mortality rates while imposing a substantial economic burden on healthcare systems. Despite its widespread clinical use, the role of esketamine, an NMDA receptor antagonist with rapid antidepressant effects, remains understudied in perioperative settings. Therefore, we...