MM120 (Lysergide) May Enhance Neuroplasticity by Post-Dose Upregulation of TrkB
European Psychiatry June 1, 2026 G. Smagin, J. Tripp
Introduction MM120 (lysergide D-tartrate, a formulation of LSD) is under development as a potential treatment for generalized anxiety and major depressive disorders. How psychedelic drugs interact at the TrkB receptor, a key target of neuroplasticity, is not reported. Objectives The study evaluated binding and functional activity of known serotonergic psychedelic compounds and SRI fluoxetine at...