Role of Actinobacteria and Coriobacteriia in the antidepressant effects of ketamine in an inflammation model of depression
Pharmacology, Biochemistry and Behavior 2019 Nian-nian Huang, Dongyu Hua, Gaofeng Zhan et al.
ABSTRACT Ketamine, an N‐methyl‐d‐aspartic acid receptor (NMDAR) antagonist, elicits rapid‐acting and sustained antidepressant effects in treatment‐resistant depressed patients. Accumulating evidence suggests that gut microbiota via the gut‐brain axis play a role in the pathogenesis of depression, thereby contributing to the antidepressant actions of certain compounds. Here we investigated the...