Pharmacology, biochemistry, and behavior
February 1, 2025
Talita Rodrigues, Getulio Nicola Bressan, Patrícia Zorzi Juliani et al.
Schizophrenia is a mental disorder characterized by positive, negative, and cognitive symptoms which is treated with antipsychotics. However, these drugs present several side effects and, some schizophrenia symptoms, like cognitive, are difficult to treat. The peroxisome proliferator-activated receptors-gamma (PPAR-γ) are expressed in dopaminergic neurons of the midbrain participating in the...
Journal of neural transmission (Vienna, Austria : 1996)
August 1, 2024
Patrícia Zorzi Juliani, Talita Rodrigues, Getulio Nicola Bressan et al.
4 citations
Resveratrol (3,5,4'-trihydroxy-trans-stilbene), a phenol commonly found in grapes and wine, has been associated as protective in experimental models involving alterations in different neurotransmitter systems. However, studies are reporting that resveratrol could have adverse effects. This study evaluated if the association of a low dose of ketamine and resveratrol could induce behavioral...
Pharmacology, Biochemistry and Behavior
October 1, 2023
Talita Rodrigues, Getulio Nicola Bressan, Barbara Krum et al.
Schizophrenia is a chronic, debilitating mental illness that has not yet been completely understood. In this study, we aimed to investigate the effects of different doses of ketamine, a non-competitive NMDA receptor antagonist, on the positive- and negative-like symptoms of schizophrenia. We also explored whether these effects are related to changes in the immunoreactivity of GAD67, TH, and...