Iris Van der Heijden

5-HT_2A and 5-HT_2C Receptors Exert Opposing Effects on Locomotor Activity in Mice

Neuropsychopharmacology July 1, 2009 Adam L. Halberstadt, Iris Van der Heijden, Michael A Ruderman et al.

Although it is well established that hallucinogens act as 5-HT_2A and 5-HT_2C receptor agonists, little is known about the relative contributions of 5-HT_2A and 5-HT_2C receptors to the acute behavioral effects of these drugs. The behavioral pattern monitor was used to characterize the effects of the hallucinogen 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on locomotor and investigatory...