Esketamine-mediated alleviation of electroconvulsive shock-induced memory impairment is associated with the regulation of mGluR5 in depressive-like rats.
Pharmacology, Biochemistry, and Behavior March 1, 2025 Yiwei Shen, Wei Ran, Dawei Liu et al. 2 citations
Electroconvulsive therapy (ECT) is recognized as one of the most efficacious interventions for depression. However, it is associated with impairments in learning and memory functions. Ketamine has demonstrated potential in mitigating cognitive deficits. Notably, the metabotropic glutamate system is hypothesized to play a pivotal role in cognitive process regulation. Nevertheless, the...
DOI: 10.1016/j.pbb.2025.173955 (opens in new tab)
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Spravato
Electroconvulsive shock
Learning
Metabotropic glutamate receptor
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