Behavioral effects of psychedelic and non-psychedelic serotonin 2A receptor agonist drugs in pigs
Neuroscience Applied 2026 CA Madsen, M. Navarro, E. Kolesnik et al.
Background: Serotonergic psychedelics induce their psychoactive effects by stimulating the brain’s serotonin 2A receptor (5-HT2AR). In humans, a cerebral 5-HT2AR occupancy of ≥60% is required to elicit a profound psychedelic experience with psilocybin [1] and for pigs, a dose corresponding to ∼65% 5-HT2AR occupancy elicits headshakes [2]. We posit that in order to assess biochemical and...