Differential protective effects of typical versus atypical antipsychotic drugs in a phencyclidine microelectrode array model of schizophrenia
Timo Faustmann, Stephan Theiss, Philipp Görtz et al.
Abstract Phencyclidine (PCP), a non-competitive N-methyl-D-aspartate receptor antagonist, is known to produce schizophrenia-like psychosis in humans, including positive and negative symptoms as well as cognitive dysfunction. Moreover, acute administration of PCP can emulate corresponding behavioral symptoms in rodents. We investigated the effect of PCP and the possible rescuing potential of...