Adolescent Δ9-THC Exposure Differentially Affects Mice Depending on Their Personality.
Pharmaceuticals (Basel, Switzerland) June 29, 2026 Dilorom Begmatova, Liudmila Vinnikova, Natalya Zemliana et al.
Background: Adolescence is a sensitive period for brain maturation during which exposure to Δ9-tetrahydrocannabinol (THC) can induce long-lasting neurobehavioral alterations. Yet, preclinical and clinical studies report inconsistent long-term outcomes of adolescent THC exposure, ranging from clear impairments to apparently normalizing effects. We hypothesize that these discrepancies reflect...