Lasting effects of ketamine and isoflurane administration on anxiety- and panic-like behavioral responses in Wistar rats.
Life Science March 27, 2021 Máira Tereza Talma Chírico, Mariana Reis Guedes, Lucas Gabriel Vieira et al.
Ketamine (80 mg/kg) produced anxiogenic effects in male rats two and seven days after administration in the elevated T-maze test, while both 40 and 80 mg/kg doses decreased panic-like behavior. In the light/dark test, ketamine was anxiogenic. Isoflurane did not alter behavior in the elevated T-maze but reduced exploration of the open field center after seven days. Neither anesthetic caused oxidative liver damage. Ketamine reduced cellular metabolism and led to neuronal death in amygdalar primary cell cultures. The authors conclude that ketamine and isoflurane induce pronounced long-lasting anxiety-related behaviors in male rats.