Kappa opioid agonists reduce oxycodone self-administration in male rhesus monkeys.
Psychopharmacology May 1, 2020 C Austin Zamarripa, Jennifer E Naylor, Sally L Huskinson et al.
Combinations of mu and kappa opioid receptor (KOR) agonists have been proposed as potential analgesic formulations with reduced abuse liability. The current studies extend previous work by investigating the typical KOR agonist, salvinorin A, and the atypical KOR agonist, nalfurafine, as deterrents of oxycodone self-administration using a progressive ratio (PR) schedule of reinforcement. In...