Differential regulation of chromogranin A, chromogranin B and secretogranin II in rat brain by phencyclidine treatment.
Neuroscience January 1, 2001 J Marksteiner, U Weiss, C Weis et al.
Phencyclidine (PCP) alters levels of secretoneurin, a peptide derived from secretogranin II, in specific brain regions of rats. A single dose of PCP (10 mg/kg) caused a transient decrease in secretoneurin in the prefrontal cortex after 4 hours, followed by an increase after 12 hours. Repeated daily PCP for five days elevated secretoneurin levels in cortical areas and increased the number of neurons containing secretoneurin and its messenger RNA, while chromogranin A and B remained unchanged. The authors suggest these changes may reflect synaptic alterations relevant to schizophrenia.