Prepulse inhibition is different in two inbred mouse strains (CPB-K and BALB/cJ) with different hippocampal NMDA receptor densities.
Behavioural Brain Research January 6, 2006 Rainer Wolf, Henrik Dobrowolny, Kay Matzke et al.
Mice with lower NMDA receptor density in the hippocampus (CPB-K strain) show weaker sensorimotor gating—measured by prepulse inhibition (PPI)—compared to mice with higher receptor density (BALB/cJ strain). CPB-K mice also had a significantly higher acoustic startle response. PPI was reliably measured across repeated sessions over 13 weeks. The authors propose that the CPB-K mouse strain may serve as an animal model for schizophrenia, consistent with the hypo-glutamatergic hypothesis of the disorder, but further behavioral experiments are needed to establish this.