Association between age of cannabis initiation and gray matter covariance networks in recent onset psychosis
Neuropsychopharmacology March 3, 2021 Nora Penzel, Linda A. Antonucci, Linda T. Betz et al. 18 citations
Earlier cannabis initiation among people with recent-onset psychosis is associated with more severe positive symptoms and greater gray matter volume in a cerebellar network previously linked to schizophrenia. This cerebellar volume increase correlates with lower volume in an insula-temporal-frontal network also implicated in schizophrenia. The findings suggest that early cannabis use may alter the developmental trajectory of specific brain networks, increasing later psychosis risk.