Sex-Dependent Ketamine Addiction-Like Behavior Profile Following Exposure to Chronic Mild Stress
Chronic Stress 2019 Katherine N. Wright, Devin P Hagarty, C. Strong et al.
Background Ketamine has rapid antidepressant effects and shows great promise as a novel treatment for depression, but its limitations including its abuse potential are poorly understood. Given that the prevalence of depression is twice as high in women as in men and that depression and substance use disorders are highly comorbid, we hypothesized that a sex-specific responsivity to behavioral...