Subanesthetic ketamine exerts antidepressant-like effects in adult rats exposed to juvenile stress.
Brain Research June 13, 2020 Katsuhiro Aikawa, Takayuki Yoshida, Yu Ohmura et al.
Juvenile stress, like that caused by childhood maltreatment, is a significant risk factor for psychiatric disorders such as depression later in life. Recently, the antidepressant effect of ketamine, a noncompetitive N-methyl-d-aspartate receptor antagonist, has been widely investigated. However, little is known regarding its efficacy against depressive-like alterations caused by juvenile...