Ketamine reverses the impaired fear memory extinction and accompanied depressive-like behaviors in adolescent mice.
Behavioural Brain Research November 6, 2019 Mei-Dan Wei, Yuhong Wang, Kun Lu et al.
Ketamine rapidly reduces depressive-like behaviors and facilitates the extinction of fear memories in adolescent mice, an effect linked to presynaptic mechanisms that restore long-term potentiation. The findings suggest a potential new treatment strategy for post-traumatic stress disorder, which affects about eight percent of the population and is characterized by impaired fear memory extinction.