S-Ketamine Mediates Its Acute and Sustained Antidepressant-Like Activity through a 5-HT1B Receptor Dependent Mechanism in a Genetic Rat Model of Depression
Frontiers in Pharmacology January 15, 2018 K. D. Du Jardin, N. Liebenberg, M. Cajina et al.
Depleting serotonin in a rat model of depression eliminates the antidepressant-like effects of S-ketamine in the forced swim test. Combining S-ketamine with a low dose of a drug that activates serotonin 1B receptors restores those effects, suggesting that activation of these receptors during testing is critical for S-ketamine's antidepressant-like activity.