Omega-3 fatty acid reverses Ketamine-induced hyperlocomotion, memory deficit and cerebral cortex neuronal injury in rats
Acta Bioscientia: Journal of Biomedical and Biological Science Research January 25, 2025 O. Onaolapo, A. Onaolapo
Omega-3 fatty acids (OMG) may protect against brain changes caused by ketamine in rats. Rats given ketamine showed increased movement, memory impairment, and higher oxidative stress and inflammation. Treatment with OMG at 250 or 500 mg/kg reversed these effects, similar to the antipsychotic olanzapine. Ketamine also caused neuronal degeneration in the cerebral cortex, which OMG partially reversed. The findings suggest OMG has neuroprotective potential, but more research is needed to confirm benefits in humans.