Mangiferin Mitigates Ketamine-Induced Dopaminergic and Glial Dysregulation and Modulates Nrf2 Expression in a Rat Schizophrenia-Like Model
Journal of Experimental Pharmacology April 1, 2026 V. A. Chukwu, G. Anyanwu, N. Nto et al.
Introduction Schizophrenia involves dopaminergic dysregulation, oxidative stress, and glial activation within motor–cognitive circuits. Mangiferin, a polyphenolic C-glucoside from Mangifera indica, exerts antioxidant and anti-inflammatory effects partly via modulation of nuclear factor erythroid 2–related factor 2 (Nrf2) signaling. This study evaluated whether mangiferin attenuates...