Targeting beta-2 adrenergic receptor attenuates schizophrenia-like behavioral effects induced by ketamine in mice: cAMP/PKA/BDNF-PEA-3 and RIM-1α signaling pathways involvement
Saudi Pharmaceutical Journal April 1, 2026 Mohammed M. Heikal, Ahmed F. Mohamed, Nora O. Abdel Rasheed et al.
The interplay between cAMP/PKA and neuroplasticity involves intricate signaling pathways that are crucial for brain function and are frequently disrupted in schizophrenia. This study sought to examine the potential neuroprotective effects of formoterol on ketamine-induced schizophrenia-like behaviors with emphasis on several PKA downstream crucial targets for schizophrenia management. Male mice...