High‐performance liquid chromatography tandem mass spectrometry method for the determination of 2CC‐NBOMe and 25I‐NBOMe in human serum
Biomedical Chromatography December 1, 2013 Justin L. Poklis, Jezelle Charles, Carl E. Wolf et al.
A new high-performance liquid chromatography triple quadrupole mass spectrometry method was developed to detect and quantify two designer drugs, 2CC-NBOMe and 25I-NBOMe, in the serum of intoxicated emergency department patients. The method uses solid-phase extraction and is linear over 30–2000 pg/mL, with a detection limit of 10 pg/mL for both compounds. Applied to two severely intoxicated patients, serum concentrations of 25I-NBOMe were 250 and 2780 pg/mL. The method is suitable for clinical toxicology testing.