Stress-sensitive antidepressant-like effects of ketamine in the mouse forced swim test
PLoS One April 15, 2019 P. Fitzgerald, Jessica Yen, B. Watson
Major depression is a stress-linked disease with significant morbidity and the anesthetic drug ketamine is of growing interest in the treatment of depression, since in responsive individuals a single dose has rapid (within hours) antidepressant effects that can be sustained for over a week in some instances. This combination of fast action and a therapeutic effect that lasts far beyond the...