Ketamine induces rapid and sustained antidepressant-like effects in chronic pain induced depression: Role of MAPK signaling pathway.
Progress in Neuro-psychopharmacology and Biological Psychiatry February 25, 2020 Muris Humo, Beyza Ayazgök, Léa J. Becker et al.
A single injection of ketamine (15 mg/kg) in mice with chronic neuropathic pain temporarily reduced mechanical hypersensitivity for less than 24 hours, but its antidepressant effect lasted at least 72 hours. Ketamine also normalized the expression of MKP-1 and phosphorylation of ERK in the anterior cingulate cortex, molecular changes that may underlie its therapeutic effects on pain-induced depression.