Ketamine's schizophrenia-like effects are prevented by targeting PTP1B.
Neurobiology of Disease May 17, 2021 Zhaohong Qin, Li Zhang, Michael A. Zasloff et al.
Subanesthetic doses of ketamine induce schizophrenia-like behaviors in mice including hyperlocomotion and deficits in working memory and sensorimotor gating. Here, we examined the effect of in vivo ketamine administration on neuronal properties and endocannabinoid (eCB)-dependent modulation of synaptic transmission onto layer 2/3 pyramidal neurons in brain slices of the prefrontal cortex, a...