Aromatase inhibition and ketamine in rats: sex-differences in antidepressant-like efficacy
Biology of Sex Differences October 24, 2023 Sandra Ledesma-Corvi, Jordi Jornet-Plaza, M. García-Fuster
Ketamine is a novel fast-acting antidepressant recently approved for treatment-resistant depression. Since preclinical studies showed sex differences in its efficacy, probably driven by sex hormones (estrogens and testosterone), we evaluated the antidepressant-like effects of ketamine in male and female rats when the biosynthesis of estrogens was inhibited. To do so, we utilized letrozole, an...