Methoxetamine produces rapid and sustained antidepressant effects probably via glutamatergic and serotonergic mechanisms
Neuropharmacology November 1, 2017 Chrislean Jun Botanas, June Bryan De la Peña, Raly James Perez Custodio et al.
Depression afflicts around 16% of the world's population, making it one of the leading causes of disease burden worldwide. Despite a number of antidepressants available today, the delayed onset time and low remission rate of these treatments are still a major challenge. The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has shown to produce rapid and sustained antidepressant effects...