Effects of NMDA antagonists ketamine, methoxetamine and phencyclidine on the odor span test of working memory in rats
Experimental and Clinical Psychopharmacology February 1, 2018 Michael Mathews, R. N. Mead, M. Galizio
The glutamate hypothesis proposes that N-Methyl-D-aspartate (NMDA) receptor hypofunction underlies cognitive and perhaps other schizophrenic symptoms. The present study used the odor span task to assess the effects of NMDA antagonists on remembering multiple stimuli in rodents. This task uses an incrementing nonmatching-to-sample procedure in which responses to a new olfactory stimulus are...