Anna Mutti

2 papers in the library · publishing 2016

Papers

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The ketamine-like compound methoxetamine substitutes for ketamine in the self-administration paradigm and enhances mesolimbic dopaminergic transmission.

Psychopharmacology June 1, 2016 Anna Mutti, Sonia Aroni, Paola Fadda et al.

Recently, an increasing number of emergency cases due to a novel ketamine-like drug, methoxetamine (MXE), were reported in several countries. However, very little is known about the neuropsychopharmacological and reinforcing profile of this compound. Our study aims to investigate the effects of MXE on self-administration (SA) behaviour in comparison to ketamine and on dopaminergic transmission....

DOI: 10.1007/s00213-016-4275-0 Full text Ketamine Abuse liability Dopamine Drug substitution +5

The ketamine analogue methoxetamine generalizes to ketamine discriminative stimulus in rats.

Behavioural Pharmacology April 1, 2016 Cristiano Chiamulera, Federica Armani, Anna Mutti et al.

Methoxetamine (MXE) is a chemical analogue of ketamine. Originally proposed as a ketamine-like fast-acting antidepressant, owing to similar N-methyl-D-aspartate blocker properties, it is now scheduled for reports of hallucinations and psychosis similar to ketamine and lysergic acid. As little is known about the addictive properties of MXE, the aim of this study was to investigate the similarity...

DOI: 10.1097/fbp.0000000000000221 Full text