Antidepressant‐like effect of AMPA and ketamine combination in male Wistar ‐Kyoto rats
The FASEB Journal April 1, 2012 Luli R Akinfiresoye, D. M. Lovinger, Y. Tizabi
Studies have shown that therapeutics that act on the glutamatergic system could provide a novel mechanistic approach for the treatment of depression. We previously reported that ketamine, an NMDA antagonist, has a rapid and lasting antidepressant effect both acutely and chronically on depressive‐like behavior in Wistar‐Kyoto (WKY) rats ( Soc Neurosci Abst 2008) . Other studies had suggested...