Neurociência dos psicodélicos: fundamentos bioquímicos, segurança e indicações emergentes em psiquiatria
Contribuciones a las Ciencias Sociales May 21, 2025 Rodrigo Vitorino Gonçalves, Monica Montemor Bertazo, José Claudio Pereira da Silva et al.
Psychedelics such as ayahuasca, DMT, psilocybin, and LSD act primarily on serotonin 5-HT2A receptors, inducing intense subjective effects like hallucinations and mystical experiences that may improve patients' emotional and psychological state. Psilocybin and ayahuasca show promising short- and long-term benefits for treatment-resistant depression and anxiety. However, safety requires strict control due to risks of adverse reactions such as anxiety and perceptual disturbances. The pharmacological complexity, including DMT's interaction with MAO-A inhibitors in ayahuasca, highlights the need for personalized administration. More rigorous clinical studies and specific guidelines are needed to ensure safe and effective use.