The effects of ketamine on typical and atypical depressive symptoms
Acta Psychiatrica Scandinavica July 17, 2020 Lawrence T. Park, David A. Luckenbaugh, Steven Pennybaker et al. 23 citations
A single intravenous dose of ketamine improved both typical/melancholic and atypical depressive symptoms in people with treatment-resistant major depressive disorder or bipolar depression. At one day after infusion, the effect was larger for typical/melancholic symptoms (Cohen's d = 0.61) than for atypical symptoms (Cohen's d = 0.41), and improvements persisted at day three. The findings suggest ketamine may have early preferential effects on typical/melancholic symptoms, though it benefits both symptom dimensions.