The neurotrophic and antidepressant actions of BDNF and VEGF require interactive signaling
Proceedings for Annual Meeting of The Japanese Pharmacological Society 2018 Satoshi Deyama, Eunyoung Baing, T. Kato et al.
Previous studies have shown that activity-dependent release of brain-derived neurotrophic factor (BDNF) in the medial prefrontal cortex (mPFC) is required for the antidepressant actions of ketamine. Recently, we have found that neuronal vascular endothelial growth factor (VEGF),signaling in the mPFC also plays a crucial role in the antidepressant actions of this rapid acting agent. However, it...