Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation
Journal of Clinical Investigation April 16, 2019 T. Kato, Santosh Pothula, Rong-Jian Liu et al. 88 citations
Preclinical studies demonstrate that rapid acting antidepressants, including ketamine require stimulation of mTORC1 signaling. This pathway is regulated by neuronal activity, endocrine and metabolic signals, notably the amino acid leucine, which activates mTORC1 signaling via binding to the upstream regulator sestrin. Here, we examined the antidepressant actions of NV-5138, a novel highly...