Ketamine rapidly reverses stress-induced impairments in GABAergic transmission in the prefrontal cortex in male rodents
Neurobiology of Disease November 7, 2019 Sriparna Ghosal, Catharine H. Duman, Rong-Jian Liu et al. 94 citations
Dysfunction of medial prefrontal cortex (mPFC) in association with imbalance of inhibitory and excitatory neurotransmission has been implicated in depression. However, the precise cellular mechanisms underlying this imbalance, particularly for GABAergic transmission in the mPFC, and the link with the rapid acting antidepressant ketamine remains poorly understood. Here we determined the...
DOI: 10.1016/j.nbd.2019.104669 (opens in new tab)
Ketamine
Gabaergic
Neurotransmission
Inhibitory postsynaptic potential
+6