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James J. Mahoney

1 paper in the library · 251 citations · publishing 2013

Papers

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Plasma brain derived neurotrophic factor (BDNF) and response to ketamine in treatment-resistant depression

The International Journal of Neuropsychopharmacology October 8, 2013 Colin N. Haile, James W. Murrough, Dan V. Iosifescu et al. 251 citations

Ketamine produces rapid antidepressant effects in treatment-resistant depression (TRD), but the magnitude of response varies considerably between individual patients. Brain-derived neurotrophic factor (BDNF) has been investigated as a biomarker of treatment response in depression and has been implicated in the mechanism of action of ketamine. We evaluated plasma BDNF and associations with...