The Wim Hof method (WHM) is a behavioral intervention technique that consists of deep breathing exercises, cold exposure and meditation. In light of the crucial role of the cannabinoid system in modulating neurotransmitter release through a negative feedback mechanism that aims at the maintenance of network homeostasis, our study investigated changes in cannabinoid type 1 (CB1) receptor binding...
The defense of body temperature against environmental thermal challenges is a core objective of homeostatic regulation governed by the autonomic nervous system. Autonomous mechanisms of thermoregulation are only weakly affected by top-down modulation, allowing only transient tolerance for extreme cold. There is however, anecdotal evidence of a unique set of individuals known for extreme cold...