Acute Effects of Cannabis on Symptoms of Obsessive-Compulsive Disorder.
Journal of Affective Disorders January 15, 2021 Dakota Mauzay, Emily M LaFrance, Carrie Cuttler
Inhaling cannabis is associated with short-term reductions in OCD symptoms. In an analysis of 1,810 cannabis use sessions tracked by 87 self-identified OCD patients via the Strainprint® app, compulsions dropped by 60%, intrusions by 49%, and anxiety by 52% from before to after inhalation. Higher CBD concentrations and higher doses predicted larger reductions in compulsions. Over 31 months, later sessions showed smaller reductions in intrusions, suggesting possible tolerance. Baseline symptom severity and dose remained stable. The absence of a placebo control and the self-selected sample limit causal conclusions.