Characteristic patterns of EEG oscillations in sheep (Ovis aries) induced by ketamine may explain the psychotropic effects seen in humans.
Scientific Reports June 11, 2020 A U Nicol, A J Morton
Ketamine, an anesthetic and analgesic increasingly used recreationally and as a treatment for depression and PTSD, produces immediate and widespread changes in the brain's electrical activity. In sheep, EEG recordings showed that after sedation, brain activity alternated between low and high frequency oscillations in short bursts, likely underlying the dissociative and hallucinogenic effects of the drug. At the highest dose tested (24 mg/kg), cortical EEG activity completely stopped in most animals for several minutes before resuming, a phenomenon that may explain the 'k-hole' experience sought by recreational users.