Propofol enhances memory formation via an interaction with the endocannabinoid system.
Anesthesiology June 1, 2011 Daniela Hauer, Patrizia Ratano, Maria Morena et al.
Propofol, a common general anesthetic, strengthens emotional memory consolidation when given immediately after a stressful event, unlike other sedatives. In rats trained on an avoidance task, anesthetic doses of propofol administered right after training led to significantly longer retention of the fearful memory 48 hours later, compared to a vehicle control. This memory-enhancing effect was blocked by a cannabinoid receptor antagonist, indicating it depends on the endocannabinoid system. Delayed administration of propofol or immediate post-training administration of midazolam or pentobarbital did not affect memory retention. The findings suggest propofol's influence on emotional memory may explain its association with traumatic memories after surgery.