Local REM sleep-N1-wake sleep stage mixing in narcolepsy type 1
medRxiv February 17, 2026 Constantin Weberpals, A. Specht, Natasja Bonde Andersen et al.
Abstract Type 1 narcolepsy (NT1), a disorder caused by the loss of hypocretin/orexin transmission, is characterized by daytime sleepiness and symptoms where Rapid Eye Movement (REM) sleep, a state normally occurring from middle to late in the night, can intermingle with wakefulness. This results in cataplexy and sleep paralysis, episodes of muscle paralysis when awake, or in the generation of...