HealthcareOctober 20, 2026Olivia Hill, Riley K Imlay, Ankit Chalia et al.
Pseudobulbar affect (PBA) is characterized by recurrent, involuntary episodes of crying or laughing that may be disproportionate or incongruent with an individual’s underlying mood. Although dextromethorphan/quinidine is FDA-approved for PBA, clinical experience with dextromethorphan/bupropion for this indication remains limited. We describe a 42-year-old woman with a history of resected right...
CureusNovember 1, 2023Maninder Sohi, Lakshit Jain, Michael Ang-Rabanes et al.
Major depressive disorder (MDD) is associated with both insomnia and hypersomnia, but it predominantly decreases sleep continuity and leads to a decrease in rapid eye movement (REM) latency, an increase in REM sleep duration, and an increase in REM density. Some of these changes persist even when MDD is treated and can be associated with a recurrence of MDD. Antidepressants can potentially...