97. NEURAL AND BEHAVIORAL EVIDENCE FROM REINFORCEMENT LEARNING CONVERGE IN SUPPORT OF RELAXED BELIEFS UNDER LSD
International Journal of Neuropsychopharmacology August 1, 2025 Jonathan W. Kanen, Andrea I. Luppi, Q. Luo et al.
Abstract Background The REBUS (RElaxed Beliefs Under pSychedelics) and the anarchic brain model of psychedelic drug action proposes that confidence in beliefs – and thus expectations (priors) – are relaxed under these drugs. The brain makes inferences to minimize surprise, or discrepant expectations and outcomes (prediction error [PE]), and better model the world. We recently showed that the...