Aβ-induced vulnerability propagates via the brain’s default mode network
Nature Communications June 4, 2019 T. Pascoal, S. Mathotaarachchi, M. Kang et al.
The link between brain amyloid-β (Aβ), metabolism, and dementia symptoms remains a pressing question in Alzheimer’s disease. Here, using positron emission tomography ([18F]florbetapir tracer for Aβ and [18F]FDG tracer for glucose metabolism) with a novel analytical framework, we found that Aβ aggregation within the brain’s default mode network leads to regional hypometabolism in distant but...