Chemogenetic stimulation of tonic locus coeruleus activity strengthens the default mode network
Science Advances April 1, 2022 E. Oyarzabal, Li-Ming Hsu, Manasmita Das et al.
The default mode network (DMN) of the brain is functionally associated with a wide range of behaviors. In this study, we used functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and spectral fiber photometry to investigate the selective neuromodulatory effect of norepinephrine (NE)–releasing noradrenergic neurons in the locus coeruleus (LC) on the mouse DMN....