Biophysical mechanism of the interaction between default mode network and working memory network
Cognitive Neurodynamics December 1, 2021 Yue Yuan, Xiaochuan Pan, Rubin Wang
A theoretical model coupling the default mode network (DMN) and working memory network (WMN) simulates neural dynamics during encoding, maintenance, and retrieval phases. AMPA channels produce synchronous oscillations that shift oscillation patterns in both networks. Different NMDA conductance between networks generates multiple neural activity modes, potentially switching network states across memory phases. The number of sequentially memorized stimuli relates to energy consumption determined by internal parameters, with the DMN contributing to more stable working memory. Different memory phases correspond to different functional connections between DMN and WMN, with coupling strengths differing in phase synchronization. Phase synchronization characteristics of contained energy match observed negative and positive correlations between networks from fMRI experiments.